restriction site-associated DNA

Improved reference genome of Aedes aegypti informs arbovirus vector control

We participated to this study by illustrating the value of the new assembly (AaegL5) for mapping quantitative trait loci (QTLs). We used restriction site-associated DNA (RAD) markers to locate QTLs underlying dengue virus (DENV) vector competence.

Extensive Genetic Differentiation between Homomorphic Sex Chromosomes in the Mosquito Vector, Aedes aegypti

We provide evidence that sex chromosomes in *Ae. aegypti* are genetically differentiated between males and females over a region much larger than the sex-determining region (SDR). Our linkage mapping intercrosses failed to detect recombination between X and Y chromosomes over a 123-Mbp region (40% of their physical length) containing the SDR. Sex-differentiated genomic region was associated with a significant excess of male-to-female heterozygosity and contained a small cluster of loci consistent with Y-specific null alleles.